Assuntos
Dengue/imunologia , Soros Imunes , Animais , Dengue/patologia , Pulmão/patologia , CamundongosRESUMO
Three patients showing smallpox- and chickenpox-like lesions simultaneously were investigated virologically. Both infections were confirmed in the laboratory and, in one case, by electron microscopy.
Assuntos
Varicela/complicações , Varíola/complicações , Adolescente , Adulto , Herpesvirus Humano 3/isolamento & purificação , Humanos , Masculino , Pessoa de Meia-Idade , Vírus da Varíola/isolamento & purificaçãoRESUMO
The paper presents clinical observations on 1 233 persons with smallpox who were admitted to the Infectious Diseases Hospital, Calcutta, in 1973. The disease was of the modified type in 53 patients (4.3%), the ordinary type in 717 (58.2%), the flat type in 249 (20.2%), and the haemorrhagic type in 214 (17.3%). The fatality of these types of smallpox was found to be 5.7%, 26.8%, 88.4%, and 98.1%, respectively, and the overall case fatality was 50.7%. The haemorrhagic type was found mainly among older patients and affected males more often than females. The vaccination status of 1 218 patients was known. Of these, 901 (73.9%) were unvaccinated and had a fatality rate of 53.4%, whereas the 317 (26.1%) vaccinated patients had a fatality rate of 36.5%. Among the 201 haemorrhagic cases, 145 patients were unvaccinated (16.09% of the total number unvaccinated) and 56 (17.67%) had been vaccinated. Of 34 patients vaccinated during the incubation period, 19 (41.1%) died, whereas of 18 patients who had been vaccinated after the onset of fever, but before the appearance of rash, 9 (50%) died.
Assuntos
Varíola , Adolescente , Adulto , Criança , Pré-Escolar , Feminino , Humanos , Índia , Lactente , Masculino , Pessoa de Meia-Idade , Varíola/epidemiologia , Varíola/mortalidade , Varíola/prevenção & controle , VacinaçãoRESUMO
Blood samples from 57 contacts of 6 smallpox cases were tested for haemagglutination-inhibiting (HI) and neutralizing antibodies. All 6 contacts who subsequently developed smallpox were unvaccinated and had neutralizing antibody titres of 10 or less. However, 6 unvaccinated contacts with similar antibody levels did not develop smallpox. None of the 41 vaccinated contacts, regardless of their antibody level, contracted the disease.
Assuntos
Anticorpos Antivirais/análise , Imunidade , Varíola/imunologia , Adolescente , Adulto , Idoso , Criança , Pré-Escolar , Feminino , Humanos , Índia , Masculino , Pessoa de Meia-Idade , Varíola/prevenção & controle , VacinaçãoRESUMO
Log titres of smallpoxvirus (pock-forming units per 0.1 g of scab) were estimated in scabs from 5 patients from the 13th to the 24th days of illness. They were found to vary from 3.72 to 6.54 with no diminution as convalescence progressed, and they were not related to the primary vaccination status of the patient or the clinical severity of the disease.
